Research in IMO
Ongoing projects
Comprehensive analysis of the ABCA4 gene: characterization of new pathogenic variants
A great number of patients affected by retinal dystrophies with macular involvement, such as Stargardt's disease, have mutations in ABCA4, a complex and large gene. The aim of this research is to study this gene to improve the diagnosis and treatment of these pathologies.
MYOPRED
Influence of posterior vitreous detachment on retinal detachment after lens surgery in myopic eyes.
Holocore FUP
Long-term safety and follow-up study after autologus cultivated limbal stem cells transplantation for restoretion of corneal epithelium in patients with limbal stem deficiency due to ocular burns.
Project history
Mass sequencing of exomes for the identification of new genes and variants responsible for retinal dystrophies
Retinitis pigmentosa, with a prevalence of 1 in 4,000 people and more than one million sufferers worldwide, is the most common retinal dystrophy. These diseases are neurodegenerative and caused by the death of the photoreceptors and cells of the retinal pigment epithelium.
Harrier
Phase III: Two-year, randomised, double-blind, multicentre, two-group trial comparing the efficacy and safety of 6 mg RTH258 compared to aflibercept in subjects with wet age-related macular degeneration.