Research

Research
Research is the main activity of the IMO Foundation. By combining basic research and clinical research, and through an unique model where geneticists and ophthalmologists work together, we seek the progress of ophthalmology in order to find a solution to ocular pathologies for which there is still no cure.

Research in IMO

The IMO is at the forefront of research into the latest developments and contributes to the main clinical trials of the day as a member of the EVICR (European Vision Institute Clinical Research Network). The IMO’s leadership and innovative approach are also reflected in a unique and pioneering commitment to translational research, in which ophthalmologists and geneticists work side by side to advance faster in the prevention, diagnosis and treatment of hereditary eye diseases.

Ongoing projects

On this page you will find the ongoing projects that IMO Foundation is currently developing. In the field of clinical research, the aim of the projects currently under development is not only to continue improving the prognosis of patients with certain pathologies, but also to offer, for the first time, effective solutions to diseases that currently have no treatment. This is also the ultimate goal of the basic research projects, which aim to analyze in depth already known genes, as well as to identify new genes related to hereditary eye diseases.    
Investigación básica

iPS cells as a study tool and model to implement the CRISPR-CAS system in the treatment of Retinal Dystrophies

The ultimate goal of this research is to lay the foundation for the application of cell therapy in the treatment of retinal dystrophies, by implanting healthy cells, obtained from iPS cells, in the patients' affected tissues.

Investigación clínica

Holocore

Efficacy and safety of autologous cultivated limbal stem cells transplantation (ACLSCT) for restoration of corneal epithelium in patients with limbal stem cell deficiency.

Investigación clínica

Holocore FUP

Long-term safety and follow-up study after autologus cultivated limbal stem cells transplantation for restoretion of corneal epithelium in patients with limbal stem deficiency due to ocular burns. 

Project history

On this page you will find the project history that the IMO Foundation has developed since its inception. IMO's ophthalmologists, optometrists and nurses who specialise in ocular photography conduct several multi-centre clinical trials each year. These studies are in addition to the basic research projects pioneered by the Molecular Biology Laboratory.    
Investigación básica

Mass sequencing of exomes for the identification of new genes and variants responsible for retinal dystrophies

Retinitis pigmentosa, with a prevalence of 1 in 4,000 people and more than one million sufferers worldwide, is the most common retinal dystrophy. These diseases are neurodegenerative and caused by the death of the photoreceptors and cells of the retinal pigment epithelium.

Investigación clínica

ATLANTIC

A randomized, double-blind, phase IV clinical study with simulated control for the analysis of the efficacy, safety and tolerability of aflibercept intrevitrea monotherapy compared to aflibercept and concomitant photodynamic therapy in patients with polypodal choroidal vasculopathy.