Ongoing projects

Ongoing Projects

On this page you will find the ongoing projects that IMO Foundation is currently developing.

In the field of clinical research, the aim of the projects currently under development is not only to continue improving the prognosis of patients with certain pathologies, but also to offer, for the first time, effective solutions to diseases that currently have no treatment. This is also the ultimate goal of the basic research projects, which aim to analyze in depth already known genes, as well as to identify new genes related to hereditary eye diseases.

 

 

Investigación básica

Identification of new genetic variants responsible for Stickler Syndrome

The Stickler Syndrome encompasses several genetic diseases, which cause various eye disorders and are difficult to diagnose. For this reason, the objective of this research is to identify all the genes involved in these pathologies in order to improve the process of diagnosis and treatment.

Investigación básica

iPS cells as a study tool and model to implement the CRISPR-CAS system in the treatment of Retinal Dystrophies

The ultimate goal of this research is to lay the foundation for the application of cell therapy in the treatment of retinal dystrophies, by implanting healthy cells, obtained from iPS cells, in the patients' affected tissues.

Investigación básica

Comprehensive analysis of the ABCA4 gene: characterization of new pathogenic variants

A great number of patients affected by retinal dystrophies with macular involvement, such as Stargardt's disease, have mutations in ABCA4, a complex and large gene. The aim of this research is to study this gene to improve the diagnosis and treatment of these pathologies.

Investigación básica

Identification of new retinal dystrophies genes and characterization of genotype-phenotype correlations

The aim of this research project is to identify new causative genes of retinal dystrophies, in order to contribute to the knowledge and diagnosis of these diseases.

Investigación clínica

XPLORE

A Phase III Double-Blind, Parallel Group, Multicenter Study to Compare the Efficacy and Safety of Xlucane versus Lucentis in Patients with Neovascular Age-Related Macular Degeneration

Investigación clínica

Eyeberia

A 12-month, Prospective, Open-label, Phase 4 Study to Evaluate the Efficacy and Safety of OZURDEX (Dexamethasone Intravitreal Implant) in Treatment Naïve Patients (According to Standard Clinical Practice) with Diabetic Macular Edema

Investigación clínica

Thealoz Duo

Evaluation of Ocular Surface Disease Syntoms and Patients Satisfaction with Thealoz Duo after 84 days of Daily treatment

Investigación clínica

IN-SIGHT

Efficacy and safety assessment of T4032 (unpreserved bimatoprost 0.01%) versus Lumigan 0.01% in ocular hypertensiove or glacomatous patients

Investigación clínica

PANDA

A multicenter, double-masked, randomized, dose-ranging trial to evaluate the efficacy and safety of conbercept intravitreal injection in subjects with neovascular age-related macular degeneration.

Investigación clínica

GTSCOPE

A study desease progression in genetically define subjects with geographic atrophy secondary to Age-Related Macular Degeneration

Investigación clínica

Holocore FUP

Long-term safety and follow-up study after autologus cultivated limbal stem cells transplantation for restoretion of corneal epithelium in patients with limbal stem deficiency due to ocular burns. 

Investigación clínica

BST- Cordó umbilical

Evaluation of the effectiveness and security of umbilical cord blood eyedrops for the treatment of neurotrophic keratitis.

Investigación clínica

MYOPRED

Influence of posterior vitreous detachment on retinal detachment after lens surgery in myopic eyes.

Investigación clínica

ENDOART

Prospective, feasibility study to evatuate the safety of the EndoArt for treatment of subjects suffering from corneal edema.

Investigación clínica

PRGF-Endoret

Randomised, parallel-group, multicentre, blind to evaluators clinical trial to assess the efficacy and safety of PRGF-Endoret eye drops in patients with stage 2 and 3 neurotrophic keratitis.

Investigación clínica

Holocore

Efficacy and safety of autologous cultivated limbal stem cells transplantation (ACLSCT) for restoration of corneal epithelium in patients with limbal stem cell deficiency.