Project history

Project history
The ophthalmologists, optometrists and nurses who specialise in ocular photography at the IMO carry out several multicentre clinical trials a year, of which the IMO is often the coordinator or main leading centre in Spain. These trials join the pioneering projects carried out by the genetics laboratory.
Investigación clínica

Rhine

Multi-center, randomized, double masking, controlled, multicenter Phase III study with active comparator to evaluate the efficacy and safety of RO6867461 in patients with diabetic macular edema.

Investigación clínica

OMASPECT

Extension study, open and multicentre to assess the safety and tolerability of long-term lampalizumab in patients with geographic atrophy secondary to age-related macular degeneration who have completed a study sponsored by ROCHE.

Investigación clínica

Bioimage

Phase IV clinical trial to evaluate genetic variants of the VEGF pathway as biomarkers of efficacy of aflibercept treatment in patients with neovascular age-related macular degeneration (AMD).

Investigación clínica

REALE

Evaluation of the effectiveness of aflibercept intravitreous injection (IVT) in clinical practice in non treated patients with Neovascular Age-Related Macular Degeneration.  

Investigación clínica

EDOF

Clinica evaluations of the clinical performance of Phakic IOL.      

Investigación clínica

EFOS

Clinical trial to evaluate the effects of Fydrane® and standard topical mydriatics and anaesthetics protocol on ocular surface after cataract surgery.      

Investigación clínica

LT4020-302

Performance and safety assessment of t4020 combined with standard post-operative therapy versus standard post-operative therapy in managing corneal epithelial defect following epi-off accelerated corneal cross-linking.

Investigación clínica

Helix

A double-masked study of SYL1001 in patients with moderate to dry eye disease (DED)

Investigación clínica

VIOLET

An open-label, randomized, active-controlled, parallel-group, Phase-3b study of the efficacy, safety, and tolerability of three different treatment regimens of 2 mg aflibercept administered by intravitreal injections to subjects with diabetic macular edema (DME)

Investigación clínica

ATLANTIC

A randomized, double-blind, phase IV clinical study with simulated control for the analysis of the efficacy, safety and tolerability of aflibercept intrevitrea monotherapy compared to aflibercept and concomitant photodynamic therapy in patients with polypodal choroidal vasculopathy.

Investigación clínica

NEUTON

Phase IV clinical trial to evaluate the efficacy of aflibercept in Naïve patients with macular edema secondary to central retinal vein occlusion (CRVO) in Treat and extend (TAE) individualized treatment regimen.

Investigación clínica

FOVISTA

Investigation of AcrySof® IQ PanOptix™ Presbyopia-Correcting Intraocular Lens (IOL) Model TFNT00.

Investigación básica

Mass sequencing of exomes for the identification of new genes and variants responsible for retinal dystrophies

Retinitis pigmentosa, with a prevalence of 1 in 4,000 people and more than one million sufferers worldwide, is the most common retinal dystrophy. These diseases are neurodegenerative and caused by the death of the photoreceptors and cells of the retinal pigment epithelium.

Investigación clínica

Spectri

Phase III, multicentre, randomised, double-blind, sham-controlled trial to assess the efficacy and safety of lampalizumab administered by intravitreal injection to patients with geographic atrophy secondary to age-related macular degeneration.

Investigación clínica

Aqua

Open-label phase IV trial to examine the change of vision-related quality of life in subjects with diabetic macular oedema (DMO) during treatment with intravitreal injections of 2 mg aflibercept according to EU label for the first year of treatment.

Investigación clínica

Premed

Phase IV: Prevention of macular oedema in cataract surgery. PREMED. Non-commercial research.

Investigación clínica

Harrier

Phase III: Two-year, randomised, double-blind, multicentre, two-group trial comparing the efficacy and safety of 6 mg RTH258 compared to aflibercept in subjects with wet age-related macular degeneration.

Investigación clínica

Artemis

Efficacy and safety of slow-release bimatoprost in patients with open-angle glaucoma or ocular hypertension.

Investigación clínica

Azure

Randomised, active-controlled, parallel group, phase III trial on the efficacy, safety and tolerability of 2 mg aflibercept administered with intyravidial injections using two different regimens of treatment for subjects with neovascular age-related macular degeneration.

Investigación clínica

Cedar

Safety and efficacy of abiciparpegol (AGN-150998) in patients with neovascular age-related macular degeneration.

Investigación clínica

Biotek-Padciclo

Phase II, multicentre, randomised, double-masked, 4 parallel arms, controlled, 6-month trial designed to evaluate the safety and efficacy of PAD ciclosporin (CsA 0.06% and 0.03%) ophthalmic dispersion administered once daily in combination with lubricant therapy and a 3-month post-treatment safety follow-up in moderate to severe dry eye patients.

Investigación clínica

Atlantic

Phase IV, randomised, double-blind trial with simulated control for the analysis of the efficacy, safety and tolerability of aflibercept intravenous monotherapy compared to aflibercept and concomitant photodynamic therapy in patients with polypodal choroidal vasculopathy.

Investigación clínica

IRIS II

Compensation for blindness with the Intelligent Retinal Implant System (IRIS V2) in patients with retinal dystrophy.

Investigación clínica

Duoprost

Phase III: Assessment of the efficacy and safety of a fixed combination of unpreserved latanoprost drops and timolol 0.5% (T2347) versus Xalacom® in patients with ocular hypertension or glaucoma.

Investigación clínica

PanOptix

Investigation of AcrySof® IQ PanOptix™ Presbyopia-Correcting Intraocular Lens (IOL) Model TFNT00.