Research

Research
Research is the main activity of Fundación IMO. By combining basic research and clinical research, and through an unique model where geneticists and ophthalmologists work together, we seek the progress of ophthalmology in order to find a solution to ocular pathologies for which there is still no cure.

Research in IMO

The IMO is at the forefront of research into the latest developments and contributes to the main clinical trials of the day as a member of the EVICR (European Vision Institute Clinical Research Network). The IMO’s leadership and innovative approach are also reflected in a unique and pioneering commitment to translational research, in which ophthalmologists and geneticists work side by side to advance faster in the prevention, diagnosis and treatment of hereditary eye diseases.

Ongoing projects

In the field of clinical research, the objective of projects currently under development is not only to improve the prognosis of patients with certain diseases, but also to offer, for the first time, an effective solution to diseases that are currently untreatable. This is also the ultimate goal of genetic studies, whose aim is to provide in-depth analysis of already known genes and identify new genes related to retinal dystrophies.
Investigación básica

Identification of new retinal dystrophy genes and characterisation of genotype/phenotype correlations

Retinal dystrophies (RD) are a heterogeneous group of hereditary diseases that are characterised by the degenerative effect that they have on the photoreceptors and cells of the retinal pigment epithelium.

Investigación clínica

IN-SIGHT

Efficacy and safety assessment of T4032 (unpreserved bimatoprost 0.01%) versus Lumigan 0.01% in ocular hypertensiove or glacomatous patients

Investigación clínica

PRGF-Endoret

Randomised, parallel-group, multicentre, blind to evaluators clinical trial to assess the efficacy and safety of PRGF-Endoret eye drops in patients with stage 2 and 3 neurotrophic keratitis.

Project history

The ophthalmologists, optometrists and nurses who specialise in ocular photography at the IMO carry out several multicentre clinical trials a year, of which the IMO is often the coordinator or main leading centre in Spain. These trials join the pioneering projects carried out by the genetics laboratory.
Investigación básica

Mass sequencing of exomes for the identification of new genes and variants responsible for retinal dystrophies

Retinitis pigmentosa, with a prevalence of 1 in 4,000 people and more than one million sufferers worldwide, is the most common retinal dystrophy. These diseases are neurodegenerative and caused by the death of the photoreceptors and cells of the retinal pigment epithelium.

Investigación clínica

IRIS II

Compensation for blindness with the Intelligent Retinal Implant System (IRIS V2) in patients with retinal dystrophy.